82404-39-5

Basic information

• Product Name: 1-(4-methylphenyl)-2-(4-trifluoromethylphenyl)acetylene
• Synonyms: 1-(4-methylphenyl)-2-(4-trifluoromethylphenyl)acetylene
• CAS NO: 82404-39-5
• Molecular Weight: 260.259
• Mol File: 82404-39-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1-(4-methylphenyl)-2-(4-trifluoromethylphenyl)acetylene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)-2-(4-trifluoromethylphenyl)acetylene(82404-39-5)
• EPA Substance Registry System: 1-(4-methylphenyl)-2-(4-trifluoromethylphenyl)acetylene(82404-39-5)

Safety Data

• Hazardous Substances Data: 82404-39-5(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 705-31-7 4-trifluoromethylphenylacetylene 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 313343-88-3 1-(bromoethynyl)-4-(trifluoromethyl)benzene 
• 112176-19-9 triisopropoxy(4-methylphenyl)titanium 
• 368-94-5 4-trifluoromethyl-benzoyl fluoride 
• 4186-14-5 1-(2-(trimethylsilyl)ethynyl)toluene 
• 350-42-5 4-methylbenzoyl fluoride 
• 40230-95-3 1-(4-trifluoromethylphenyl)-2-trimethylsilylethyne 
• 131356-53-1 1-(2,2-dibromovinyl)-4-(trifluoromethyl)benzeney 
• 5720-05-8 4-methylphenylboronic acid 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 106-38-7 para-bromotoluene 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 86568-05-0 (C₁₀H₄(OH)(C₆H₄CH₃)(C₆H₄CF₃)OCH₃)Cr(CO)3 
• 82421-72-5 (C₁₀H₄(OH)(C₆H₄CF₃)(C₆H₄CH₃)OCH₃)Cr(CO)3 
• 82421-86-1 Tricarbonyl-[1-4:9,10-η6-[4-methoxy-2-(4-methylphenyl)-3-[4-(trifluormethyl)phenyl]-1-naphthol]]chrom(0) 
• 1437733-56-6 (Z)-1,3,5-trimethyl-2-(1-p-tolyl-2-(4-(trifluoromethyl)phenyl)vinyl)benzene 
• 1437733-73-7 (E)-1-methyl-4-(1-phenyl-2-(4-(trifluoromethyl)phenyl)vinyl)benzene 
• 143958-88-7 (E)-1-methyl-4-(4-(trifluoromethyl)styryl)benzene 
• 526202-12-0 Cp₂Zr(C₄-3,4-(p-C₆H₄CF₃)2-2,5-(C₆H₄Me)2) 
• 526202-14-2 Cp₂Zr(C₄-3,5-(p-C₆H₄CF₃)2-2,4-(C₆H₄Me)2) 
• 526202-18-6 Cp₂Zr(C₄-2,5-(p-C₆H₄CF₃)2-3,4-(C₆H₄Me)2) 

Relevant articles and documents

Highly efficient synthesis of 1,2-disubstituted acetylenes derivatives from the cross-coupling reactions of 1-bromoalkynes with organotitanium reagents

A Highly efficient route for the synthesis of 1,2-disubstituted acetylene derivatives has been developed by nickel catalyzed cross-couplings of alkynyl halides with aryl titanium reagents under mild conditions. This has given corresponding cross-coupling products good to excellent isolated yields of up to 92 %. The aryls bearing electron-donating or electron-withdrawing groups in either alkynylhalides or aryltitanium substrates gave cross-coupling products good yields. This process was simple and easily performed, which provides an efficient method for the synthesis of 1,2-disubstituted acetylenes derivatives.

Palladium/copper-cocatalyzed decarbonylative alkynylation of acyl fluorides with alkynylsilanes: Synthesis of unsymmetrical diarylethynes

Palladium/copper-cocatalyzed decarbonylative alkynylation of acyl fluorides with alkynylsilanes is described. This reaction not only effectively inhibits the formation of undesired homocoupled products by avoiding the addition of a base, but also exhibits a wide substrate scope to provide a general access to diverse unsymmetrical diarylethynes.

Palladium-Catalyzed Desulfitative Cross-Coupling of Arylsulfonyl Hydrazides with Terminal Alkynes: A General Approach toward Functionalized Internal Alkynes

A palladium-catalyzed Sonogashira-type coupling between arylsulfonyl hydrazides and terminal alkynes via Ar(C)-S bond cleavage is disclosed, which enables the general synthesis of functionalized internal alkynes, especially the Br-substituted ones, in good to excellent yields under acid- and base-free conditions.