946511-63-3Relevant articles and documents
Phosphoramidate prodrugs of 2′-C-methylcytidine for therapy of hepatitis C virus infection
Gardelli, Cristina,Attenni, Barbara,Donghi, Monica,Meppen, Malte,Pacini, Barbara,Harper, Steven,Di Marco, Annalise,Fiore, Fabrizio,Giuliano, Claudio,Pucci, Vincenzo,Laufer, Ralph,Gennari, Nadia,Marcucci, Isabella,Leone, Joseph F.,Olsen, David B.,MacCoss, Malcolm,Rowley, Michael,Narjes, Frank
experimental part, p. 5394 - 5407 (2010/04/30)
The application of a phosphoramidate prodrug approach to 2′-C-methylcytidine (NM107), the first nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, is reported. 2′-C-Methylcytidine, as its valyl ester prodrug (NM283), was efficacious in r