pseudohyoscyamine

Base Information

• Chemical Name: pseudohyoscyamine
• CAS No.: 280-05-7
• Molecular Formula: C7H13 N
• Molecular Weight: 111.187
• Hs Code.: 2933990090
• Mol file: 280-05-7.mol

Synonyms:1aH,5aH-Nortropane (8CI); Nortropane (7CI); Nortropan

Chemical Property of pseudohyoscyamine

Chemical Property:

• Vapor Pressure: 1.5mmHg at 25°C
• Melting Point: 307-309 °C
• Boiling Point: 169.9°C at 760 mmHg
• PKA: pKa 10.28(H2O,t =21±2,Iundefined) (Uncertain)
• Flash Point: 48.2°C
• PSA: 12.03000
• Density: 0.934g/cm³
• LogP: 1.61970
• Storage Temp.: 2-8°C

Purity/Quality:

96+% ^*data from raw suppliers

8-Azabicyclo[3.2.1]octane hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Azabicyclo[3.2.1]octane is used as a reactant in the preparation of enantiomerically pure 8-azabicyclo[3.2.1]octane derivatives.

Technology Process of pseudohyoscyamine

There total 26 articles about pseudohyoscyamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

8-benzyl-8-azabicyclo[3.2.1]octane (19079-79-9) → 8-azabicyclo[3.2.1]octane (280-05-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4039(01)81095-9

Reference yield: 83.0%

tropane (529-17-9,687966-22-9) → 8-azabicyclo[3.2.1]octane (280-05-7)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; In DCE; at 0 ℃; for 4.08333h; Heating / reflux;

Reference yield:

tropane (529-17-9,687966-22-9) + carbonochloridic acid 1-chloro-ethyl ester (50893-53-3) → 8-azabicyclo[3.2.1]octane (280-05-7)

Guidance literature:

In methanol; 1,1-dichloroethane;

upstream raw materials:

tropane

tropane; hydrochloride

nortropine

3-tropanol

Downstream raw materials:

N-chloronortropane

2-Ethylpyridine

N-hydroxynortropane

8-azabicyclo[3.2.1]octane-N-oxyl

Refernces

• 1、 Noda, Hidetoshi,Asada, Yasuko,Shibasaki, Masakatsu. "O-benzoylhydroxylamines as alkyl nitrene precursors: Synthesis of saturated N-heterocycles from primary amines". supporting information. p. 8769 - 8773. Retrieved 2020/10/12.
• 2、 -. "Novel amides useful for treating pain". Page/Page column 28. . Retrieved 2010/02/11.