D-Lysine hydrochloride

Base Information

• Chemical Name: D-Lysine hydrochloride
• CAS No.: 7274-88-6
• Molecular Formula: C6H15ClN2O2
• Molecular Weight: 182.65
• Hs Code.: 29224190
• European Community (EC) Number: 230-691-6
• UNII: KK611JDE1N
• DSSTox Substance ID: DTXSID80884365
• Wikidata: Q27124103
• Mol file: 7274-88-6.mol

Synonyms:D-Lysine hydrochloride;7274-88-6;D-Lysine monohydrochloride;D-lysine HCl;H-D-Lys-OH.HCl;D-Lysine, monohydrochloride;Lysine hydrochloride, D-;D-Lysine, hydrochloride (1:1);D-Lysine, hydrochloride;D-Lysine, HCl;Lysine, monohydrochloride, D-;(R)-2,6-Diaminohexanoic acid hydrochloride;H-D-Lys-OH.xHCl;EINECS 230-691-6;Lysine, hydrochloride, D-;UNII-KK611JDE1N;NSC 206291;KK611JDE1N;D-Lysine (monohydrochloride);(2R)-2,6-diaminohexanoic acid hydrochloride;42334-88-3;MFCD00012920;D-(-)-Lysine Monohydrochloride;C6H15ClN2O2;C6H14N2O2.ClH;NSC-206291;(R)-2,6-Diaminohexanoic acid monohydrochloride;D-Lys hydrochloride;(R)-lysine HCl salt;D-2,6-diaminohexanoic acid monohydrochloride;SCHEMBL706905;D-Lysine hydrochloride (1:1);CHEBI:53558;DTXSID80884365;CS-D1670;HY-Y1804;LYSINE, D-, MONOHYDROCHLORIDE;AKOS015924114;AC-8659;D-2,6-diaminohexanoic acid hydrochloride;AS-14183;LS-88456;D-Lysine monohydrochloride, >=98% (TLC);(2R)-2,6-diaminohexanoic acid;hydrochloride;AM20100696;L0128;EN300-93767;L-9000;A936798;Q27124103;F1905-7192;Z1741982753;D-Lysine monohydrochloride, Vetec(TM) reagent grade, >=98%

Chemical Property of D-Lysine hydrochloride

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.000123mmHg at 25°C
• Melting Point: 266 °C (dec.)(lit.)
• Boiling Point: 311.5 °C at 760 mmHg
• Flash Point: 142.2 °C
• PSA: 89.34000
• LogP: 1.72990
• Storage Temp.: Store at RT.
• Solubility.: H2O: soluble
• Water Solubility.: SOLUBLE
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 182.0822054
• Heavy Atom Count: 11
• Complexity: 106

Purity/Quality:

99% ^*data from raw suppliers

D-Lysine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: C(CCN)CC(C(=O)O)N.Cl
• Isomeric SMILES: C(CCN)C[C@H](C(=O)O)N.Cl
• Description: D-lysine hydrochloride is the hydrochloride salt form of D-lysine. D-lysine is a kind of D-form amino acid (not the natural amino acid in organisms, which is in L-form). It is often supplied to animal feed. D-Lysine is used as a component of polymers (poly-D-lysine), surfactants and biofilms to confer a positive (cationic) charge. The poly-D-lysine can be used to facilitate the attachment of proteins and cells to solid surface through enhancing the electrostatic interaction between negatively-charged ion of the cell membrane and the positively-charged ions of the culture surface. In histochemical field, it is used to coat slides to promote cell attachment.
• Uses: D-Lysine is used as a component of a wide array of polymers (poly-D-lysine), surfactants and biofilms to confer a positive (cationic) charge.

Technology Process of D-Lysine hydrochloride

There total 2 articles about D-Lysine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

D-lysine (923-27-3,3506-25-0) → D-lysine bis(hydrochloride) (70-53-1,617-68-5,657-26-1,657-27-2,7274-88-6,10098-89-2,10303-72-7,22834-80-6,28826-16-6,42334-88-3,68147-44-4,94706-35-1,26124-78-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 3h;

DOI:10.1021/acs.orglett.8b02619

Reference yield:

α-nitrocaprolactam (6804-88-2) + 2,6-Diamino-hexanoic acid; hydrochloride (70-53-1,617-68-5,657-26-1,657-27-2,7274-88-6,10098-89-2,10303-72-7,22834-80-6,28826-16-6,42334-88-3,68147-44-4,94706-35-1,26124-78-7) → 2,6-Diamino-hexanoic acid; hydrochloride (70-53-1,617-68-5,657-26-1,657-27-2,7274-88-6,10098-89-2,10303-72-7,22834-80-6,28826-16-6,42334-88-3,68147-44-4,94706-35-1,26124-78-7)

Guidance literature:

With hydrogenchloride; (S)-1-phenyl-ethylamine; hydrogen; palladium dichloride; Product distribution; 1.) DME, 20 deg C, 5 h;

DOI:10.1007/BF00953957

Reference yield: 82.0%

4-phenylazobenzoyl chloride (104-24-5) + D-lysine bis(hydrochloride) (70-53-1,617-68-5,657-26-1,657-27-2,7274-88-6,10098-89-2,10303-72-7,22834-80-6,28826-16-6,42334-88-3,68147-44-4,94706-35-1,26124-78-7) → DPAB-D-Lys (trans) (118812-46-7,118916-84-0,118916-85-1,118916-86-2)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; 1) 5 deg C, 2 h, 2) r.t., overnight;

upstream raw materials:

D-lysine

α-nitrocaprolactam

2,6-Diamino-hexanoic acid; hydrochloride

Downstream raw materials:

N_ε-(tert-butoxycarbonyl)-D-lysine

2,6-Diamino-hexanoic acid; hydrochloride

Boc-D-Har(NO2)-OH

3-aminoazepan-2-one

Refernces

• 1、 Klabunovskii, E. I.,Karpeiskaya, E. I.,Levitina, E. S.,Godunova, L. F.,Kaigorodova, L. N.. "CATALYTIC ASYMMETRIC SYNTHESIS OF L-LYSINE". . p. 1996. Retrieved 2007/10/02.