Z-D-Lys-OH

Base Information

• Chemical Name: Z-D-Lys-OH
• CAS No.: 70671-54-4
• Molecular Formula: C14H20N2O4
• Molecular Weight: 280.324
• Hs Code.: 29242990
• DSSTox Substance ID: DTXSID60426929
• Nikkaji Number: J1.960.222B
• Mol file: 70671-54-4.mol

Synonyms:Z-D-Lys-OH;70671-54-4;(R)-6-Amino-2-(((benzyloxy)carbonyl)amino)hexanoic acid;(2R)-6-amino-2-(phenylmethoxycarbonylamino)hexanoic acid;((Benzyloxy)carbonyl)-D-lysine;(2R)-6-azaniumyl-2-(phenylmethoxycarbonylamino)hexanoate;N-ALPHA-BENZYLOXYCARBONYL-D-LYSINE;N-|A-Z-D-lysine;Nalpha-Carbobenzoxy-D-lysine;N-cbz-d-lysine;N2-Cbz-D-lysine;Nalpha-Cbz-D-lysine;Z-D-LysOH;Z-D-Lys;SCHEMBL6476819;DTXSID60426929;OJTJKAUNOLVMDX-GFCCVEGCSA-N;(R)-6-AMINO-2-(BENZYLOXYCARBONYLAMINO)HEXANOIC ACID;MFCD00067713;AKOS024319540;CS-W014013;DS-9765;HY-W013297;D-Lysine,N2-[(phenylmethoxy)carbonyl]-;Z-D-Lys-OH, >=98.0% (TLC);C2136;F11004;N-alpha-BenZyloxycarbonyl-D-lysine (CbZ-D-Lys-OH);6-AMINO-2-BENZYLOXYCARBONYLAMINO-HEXANOIC ACID

Chemical Property of Z-D-Lys-OH

Chemical Property:

• Vapor Pressure: 1.07E-10mmHg at 25°C
• Melting Point: 218 °C
• Refractive Index: 1.55
• Boiling Point: 497 °C at 760 mmHg
• PKA: 3.90±0.21(Predicted)
• Flash Point: 254.4 °C
• Density: 1.206 g/cm³
• Storage Temp.: Store at RT.
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 280.14230712
• Heavy Atom Count: 20
• Complexity: 304

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-alpha-Z-D-lysine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NC(CCCCN)C(=O)O
• Isomeric SMILES: C1=CC=C(C=C1)COC(=O)N[C@H](CCCCN)C(=O)O

Technology Process of Z-D-Lys-OH

There total 4 articles about Z-D-Lys-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-nitrophenyl Nα-(benzyloxycarbonyl)-D-lysinate hydrochloride → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + Nα-carbobenzoxy-D-lysine (70671-54-4)

Guidance literature:

With tris(hydroxymethyl)aminomethane buffer; α-chymotrypsin; In water; acetonitrile; at 25 ℃; pH=7.6; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1021/jo0265075

Reference yield:

benzyloxycarbonyl-lysine (87797-02-2) → L-lysine (56-87-1,3506-25-0) + Nα-carbobenzoxy-D-lysine (70671-54-4)

Guidance literature:

With cell extract of Sphingomonas paucimobilis SC 16113; In water; at 42 ℃; for 20h; Enzymatic reaction;

DOI:10.1002/adsc.200303038

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + Nε-benzylidene-D-lysine → Nα-carbobenzoxy-D-lysine (70671-54-4)

Guidance literature:

benzyl chloroformate; N^ε-benzylidene-D-lysine; With sodium hydroxide; In ethanol; at -10 - 20 ℃; for 0.333333h;

With hydrogenchloride; In ethanol; at 50 ℃; for 0.166667h;

DOI:10.1021/ol048437p

upstream raw materials:

benzyloxycarbonyl-lysine

benzyl chloroformate

D-lysine hydrochloride

Downstream raw materials:

N-(benzyloxycarbonyl)-D-lysyl-N'-(tert-butyloxycarbonyl)-D-glutamic acid methyl ester

Refernces

• 1、 Yano, Yoshihiro,Shimada, Kenji,Okai, Jiro,Goto, Koichi,Matsumoto, Yoko,Ueoka, Ryuichi. "Fairly marked enantioselectivity for the hydrolysis of amino acid esters by chemically modified enzymes". . p. 1314 - 1318. Retrieved 2007/10/03.