2-(Methoxymethyl)benzaldehyde tosylhydrazone

Base Information

• Chemical Name: 2-(Methoxymethyl)benzaldehyde tosylhydrazone
• CAS No.: 119367-60-1
• Molecular Formula: C₁₆H₁₈N₂O₃S
• Molecular Weight: 318.397
• Mol file: 119367-60-1.mol

Synonyms:2-(Methoxymethyl)benzaldehyde tosylhydrazone

Chemical Property of 2-(Methoxymethyl)benzaldehyde tosylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(Methoxymethyl)benzaldehyde tosylhydrazone

There total 2 articles about 2-(Methoxymethyl)benzaldehyde tosylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-[(methoxymethyl)methyl]benzaldehyde (106020-70-6) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 2-(Methoxymethyl)benzaldehyde tosylhydrazone (119367-60-1)

Guidance literature:

In ethanol; 1.) 60 deg C, 3 h, 2.) room temp., 3 h, 3.) -20 deg C, overnight;

DOI:10.1021/ja00186a048

Reference yield:

2-(methoxymethyl)-benzyl alcohol (62172-88-7) → 2-(Methoxymethyl)benzaldehyde tosylhydrazone (119367-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / PCC / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 91 percent / ethanol / 1.) 60 deg C, 3 h, 2.) room temp., 3 h, 3.) -20 deg C, overnight

With pyridinium chlorochromate; In ethanol; dichloromethane;

DOI:10.1021/ja00186a048

Reference yield: 99.0%

2-(Methoxymethyl)benzaldehyde tosylhydrazone (119367-60-1) → C16H17N2O3S(1-)*Na(1+) (119391-23-0)

Guidance literature:

With sodium hydride; 1.) THF, 2h, 2.) pentane, 2h;

DOI:10.1021/ja00186a048

upstream raw materials:

2-[(methoxymethyl)methyl]benzaldehyde

toluene-4-sulfonic acid hydrazide

2-(methoxymethyl)-benzyl alcohol

Downstream raw materials:

1,3-dihydroisobenzofuran

isochromane

2-methoxymethyltoluene

α-methoxy-α,α'-dihydrobenzocyclobutene

Refernces