150698-81-0

Basic information

• Product Name: 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol
• Synonyms: 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol
• CAS NO: 150698-81-0
• Molecular Weight: 244.136
• Mol File: 150698-81-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol(150698-81-0)
• EPA Substance Registry System: 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol(150698-81-0)

Safety Data

• Hazardous Substances Data: 150698-81-0(Hazardous Substances Data)

Usage

General Description

2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol is a chemical compound with the molecular formula C10H7F6O. It is a colorless liquid with a characteristic odor. 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol is primarily used as a solvent or intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the synthesis of various chemical compounds and as a reagent in organic chemistry. 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethan-1-ol may also have applications in the field of medicine and biotechnology due to its unique chemical properties and potential pharmacological activity. However, this compound should be handled with caution as it may pose health and environmental risks if not used and disposed of properly.

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 74853-66-0 4'-trifluoromethyl-2,2,2-trifluoroacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 403648-66-8 (±)-trimethyl-2,2,2-trifluoro-1-(4-methoxyphenyl)ethoxysilane 
• 75-46-7 trifluoromethan 
• 455-13-0 4-Iodobenzotrifluoride 
• 844-40-6 diphenylmethanol trifluoroacetate 

Downstream Products

• 666836-33-5 2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethyl trifluoromethanesulfonate 
• 74853-66-0 4'-trifluoromethyl-2,2,2-trifluoroacetophenone 
• 158098-74-9 C₉H₆F₆O₂ 
• 1404446-80-5 5-bromo-2-methyl-3-nitro-6-[2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethoxy]pyridine 
• 1422984-91-5 C₁₀H₇F₆NO₃ 
• 191402-60-5 1-(1-Chloro-2,2,2-trifluoro-ethyl)-4-trifluoromethyl-benzene 

Relevant articles and documents

Five-membered heteroaromatic derivative, preparation method and application thereof

The invention belongs to the technical field of medicines, and particularly relates to a five-membered heteroaromatic compound, a composition, a preparation method and application thereof. The compound or the composition can be used as an inhibitor of a retinoid-related orphan receptor [gamma]t (ROR [gamma]t). The invention also relates to a method for preparing the compound and the composition, and application of the compound and the composition in treatment or prevention of ROR [gamma]t-mediated cancers, inflammations or autoimmune diseases of mammals, especially human beings.

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.

Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling of Secondary α-(Trifluoromethyl)benzyl Tosylates

A palladium-catalyzed C(sp3)?C(sp2) Suzuki–Miyaura cross-coupling of aryl boronic acids and α-(trifluoromethyl)benzyl tosylates is reported. A readily available, air-stable palladium catalyst was employed to access a wide range of functionalized 1,1-diaryl-2,2,2-trifluoroethanes. Enantioenriched α-(trifluoromethyl)benzyl tosylates were found to undergo cross-coupling to give the corresponding enantioenriched cross-coupled products with an overall inversion in configuration. The crucial role of the CF3 group in promoting this transformation is demonstrated by comparison with non-fluorinated derivatives.