74853-66-0 Usage
Description
4-(TRIFLUOROMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE, also known as 2,2,2-Trifluoro-1-(4-(trifluoromethyl)phenyl)ethanone, is an organic compound with a unique molecular structure featuring a trifluoromethyl group and a trifluoroacetyl group. 4-(TRIFLUOROMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE is known for its reactivity and stability, making it a valuable intermediate in the synthesis of various complex organic molecules.
Uses
Used in Pharmaceutical Industry:
4-(TRIFLUOROMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE is used as a synthetic intermediate for the development of novel pharmaceutical compounds. Its unique reactivity and stability contribute to the creation of new drugs with potential applications in various therapeutic areas.
Used in Chemical Research:
In the field of chemical research, 4-(TRIFLUOROMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE serves as a key building block for the synthesis of complex organic molecules. Its unique properties allow researchers to explore new reaction pathways and develop innovative synthetic strategies.
Used in Synthesis of Tetrahydropyranones:
4-(TRIFLUOROMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE is used as a reactant in the synthesis of tetrahydropyranones through catalytic enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones. This application highlights its importance in the development of chiral compounds, which are essential in various industries, including pharmaceuticals and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 74853-66-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,8,5 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 74853-66:
(7*7)+(6*4)+(5*8)+(4*5)+(3*3)+(2*6)+(1*6)=160
160 % 10 = 0
So 74853-66-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H4F6O/c10-8(11,12)6-3-1-5(2-4-6)7(16)9(13,14)15/h1-4H
74853-66-0Relevant articles and documents
Copper-Mediated Trifluoroacetylation of Arenediazonium Salts with Ethyl Trifluoropyruvate
Wu, Wei,Tian, Qinli,Chen, Taotao,Weng, Zhiqiang
supporting information, p. 16455 - 16458 (2016/11/11)
A copper-mediated trifluoroacetylation of various arenediazonium salts with ethyl trifluoropyruvate is reported. The reaction proceeded smoothly under mild conditions at room temperature giving trifluoromethyl aryl ketones in moderate to good yields. A variety of functional groups, including methoxy, hydroxy, ester, ketone, trifluoromethyl, and halide groups, were well tolerated. A possible reaction mechanism involving an aryl radical intermediate was proposed and supported by experimental evidence. This reaction provides a new route to trifluoromethyl aryl ketones, notable synthetic targets, from the corresponding anilines.
A new entry for the oxidation of fluoroalkyl-substituted methanol derivatives: Scope and limitation of the organoiodine(V) reagent-catalyzed oxidation
Tanaka, Yusuke,Ishihara, Takashi,Konno, Tsutomu
experimental part, p. 99 - 104 (2012/05/07)
Oxidation of various fluoroalkyl-substituted methanol derivatives under the influence of a catalytic amount of sodium 2-iodobenzenesulfonate and Oxone in CH3CN or CH3NO2 was investigated in detail. The efficiency of the newly developed oxidation was also evaluated by comparison to other oxidations, such as Dess-Martin, PDC, and Swern oxidation.
Process for preparing trifluoromethyl ketones
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, (2008/06/13)
A process is described for preparing trifluoromethyl ketones of the formula I STR1 where R has the given meanings, wherein an alcohol of the formula II STR2 is reacted with a compound of the formula IV where n has the given meaning.
