22865-48-1

Basic information

• Product Name: p-[(p-nitrophenyl)thio]toluene
• Synonyms: p-[(p-nitrophenyl)thio]toluene;(4-Methylphenyl)(4-nitrophenyl) sulfide;1-Methyl-4-[(4-nitrophenyl)thio]benzene;4-Methylphenyl 4-nitrophenyl sulfide;4-Methylphenyl(4-nitrophenyl) sulfide;4-Nitrophenyl 4-methylphenyl sulfide;4-Nitrophenyl(4-methylphenyl) sulfide
• CAS NO: 22865-48-1
• Molecular Formula: C₁₃H₁₁NO₂S
• Molecular Weight: 245.29694
• EINECS: 245-271-8
• Mol File: 22865-48-1.mol
• Article Data: 79

Chemical Properties

• Boiling Point: 412.9°Cat760mmHg
• Flash Point: 203.5°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 1.2E-06mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: p-[(p-nitrophenyl)thio]toluene(CAS DataBase Reference)
• NIST Chemistry Reference: p-[(p-nitrophenyl)thio]toluene(22865-48-1)
• EPA Substance Registry System: p-[(p-nitrophenyl)thio]toluene(22865-48-1)

Safety Data

• Hazardous Substances Data: 22865-48-1(Hazardous Substances Data)

Usage

General Description

p-[(p-nitrophenyl)thio]toluene is a chemical compound with the molecular formula C13H11NO2S. It is classified as a nitrobenzene derivative and is commonly used as an intermediate in the synthesis of various organic compounds. p-[(p-nitrophenyl)thio]toluene is often used in the production of dyes, pigments, and other specialty chemicals. It is also utilized in organic synthesis as a reagent and building block for creating more complex molecules. p-[(p-nitrophenyl)thio]toluene is a yellow crystalline solid with a strong odor and is considered to be toxic if ingested or inhaled. Due to its potential health hazards, this compound should be handled with care and in accordance with safety guidelines.

InChI:InChI=1/C13H11NO2S/c1-10-2-6-12(7-3-10)17-13-8-4-11(5-9-13)14(15)16/h2-9H,1H3

Upstream product

• 10486-08-5 sodium p-thiocresolate 
• 100-00-5 4-chlorobenzonitrile 
• 106-45-6 para-thiocresol 
• 586-78-7 para-nitrophenyl bromide 
• 100-25-4 para-dinitrobenzene 
• 40208-36-4 N-(p-nitrophenylthio)morpholine 
• 108-88-3 toluene 
• 937-32-6 4-nitrobenzenesulfenyl chloride 
• 636-98-6 p-nitrobenzene iodide 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 
• 624-31-7 4-tolyl iodide 
• 103-19-5 di(p-tolyl) disulfide 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 2937-05-5 4-nitrobenzenesulfonohydrazide 

Downstream Products

• 4094-37-5 4-nitrophenyl 4-toluenesulfonate 
• 22865-52-7 4-amino-4'-methyldiphenylsulphide 
• 109814-22-4 1-[4-(4-nitro-phenylsulfanyl)-benzyl]-piperidine; hydrobromide 
• 91933-64-1 C₂₀H₁₈N₂O₄S₂ 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 103-19-5 di(p-tolyl) disulfide 
• 14756-51-5 4-nitrophenyl p-tolyl disulfide 
• 33174-23-1 4-(4-nitro-phenylsulfanyl)-benzoic acid 
• 126585-09-9 4-(4-Nitro-phenylsulfanyl)-benzaldehyde 
• 22865-49-2 4-methyl-4'-nitro-diphenyl sulphoxide 
• 126585-02-2 4-(4-bromomethyl phenylthio)nitrobenzene 
• 111453-15-7 4-amino-4'-methyldiphenylsulphide 
• 141339-95-9 4-(p-tolyl)sulfanylbenzaldehyde 
• 104128-50-9 (4-cyanophenyl)(4-methylphenyl)sulfide 

Relevant articles and documents

Synthesis of diaryl sulfides based on copper-doped OMS-2

We describe a practical protocol for efficiently preparing diaryl sulfide compounds using Cu–OMS-2 as the catalyst. Cu–OMS-2 originates from manganese oxide octahedral molecular sieves modified with copper ions and catalyzes the C–S coupling reaction of substituted thiophenols and aryl halides. This protocol has the advantages of environmental friendliness, simple operation, high yields, good tolerance of functional groups, and the Cu–OMS-2 catalytic material can be recycled several times.

CuMoO4 Bimetallic Nanoparticles, An Efficient Catalyst for Room Temperature C?S Cross-Coupling of Thiols and Haloarenes

CuII catalyst is less efficient at room temperature for C?S cross-coupling. C?S cross-coupling by CuII catalyst at room temperature is not reported; however, doping of copper with molybdenum metal has been realized here to be more efficient for C?S cross-coupling in comparison to general CuII catalyst. The doped catalyst CuMoO4 nanoparticle is found to be more efficient than copper. The catalyst works under mild conditions without any ligand at room temperature and is recyclable and effective for a wide range of thiols and haloarenes (ArI, ArBr, ArF) from milligram to gram scale. The copper-based bimetallic catalyst is developed and recognized for C?S cross-coupling of haloarenes with alkyl and aryl thiols.

Bimetallic BaMoO4 nanoparticles for the C-S cross-coupling of thiols with haloarenes

We disclosed new bimetallic BaMoO4 nanoparticles for the C-S cross-coupling reaction. The C-S cross-coupling reaction of alkyl/aryl thiols with haloarenes was accomplished with high yields. The reaction has good functional group tolerance and selectivity. This is an efficient protocol for synthesizing the building blocks of pharmaceuticals containing C-S bonds. The catalyst is recyclable. The unactivated bromo- and 4-acetyl fluoro-arenes can well couple to afford thioethers in high yields. The reaction is believed to proceed by oxidative addition and reductive elimination.