24568-13-6

Basic information

• Product Name: TIMTEC-BB SBB000703
• Synonyms: TIMTEC-BB SBB000703;N-(4-Acetylphenyl)-2,2,2-trifluoroacetamide;AcetaMide, N-(4-acetylphenyl)-2,2,2-trifluoro-;4'-Acetyl-2,2,2-trifluoroacetanilide;ACETANILIDE, 4'-ACETYL-2,2,2-TRIFLUORO-;N-(4-ethanoylphenyl)-2,2,2-trifluoro-ethanamide
• CAS NO: 24568-13-6
• Molecular Formula: C₁₀H₈F₃NO₂
• Molecular Weight: 231.17
• Mol File: 24568-13-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 332.7°Cat760mmHg
• Flash Point: 155°C
• Appearance: /
• Density: 1.356g/cm³
• Vapor Pressure: 0.000144mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: TIMTEC-BB SBB000703(CAS DataBase Reference)
• NIST Chemistry Reference: TIMTEC-BB SBB000703(24568-13-6)
• EPA Substance Registry System: TIMTEC-BB SBB000703(24568-13-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 24568-13-6(Hazardous Substances Data)

Usage

General Description

TIMTEC-BB SBB000703 is a chemical compound primarily composed of hexane, which is a hydrocarbon in the alkane family and is commonly used as a solvent in various industrial and laboratory applications. Hexane is flammable and can cause irritation to the eyes, skin, and respiratory tract upon prolonged exposure. It is also toxic if ingested or inhaled and should be handled with caution. The compound may also contain other impurities or additives, and its specific applications or uses may vary depending on the manufacturer or supplier.

InChI:InChI=1/C10H8F3NO2/c1-6(15)7-2-4-8(5-3-7)14-9(16)10(11,12)13/h2-5H,1H3,(H,14,16)

Upstream product

• 354-38-1 2,2,2-trifluoroacetamide 
• 13329-40-3 4-Iodoacetophenone 
• 99-90-1 para-bromoacetophenone 
• 407-25-0 trifluoroacetic anhydride 
• 171364-81-1 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone 
• 354-32-5 trifluoracetyl chloride 
• 99-92-3 p-aminobenzophenone 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 108-24-7 acetic anhydride 

Downstream Products

• 1139857-64-9 N-[4-(1-cyano-1-hydroxyethyl)phenyl]-2,2,2-trifluoroacetamide 
• 77764-50-2 Oxo-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid ethyl ester 
• 85849-70-3 N-{4-[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-thiazol-2-yl}-oxalamic acid ethyl ester 
• 78982-82-8 rac-N-{4-[2-(tert-butylamino)-1-hydroxyethyl]phenyl}-2-chloroacetamide 
• 56138-70-6 rac-1-(4-aminophenyl)-2-(tert-butylamino)ethanol 

Relevant articles and documents

Amination reagent as well as preparation method and application thereof

The invention discloses an amination reagent as well as a preparation method and application thereof. The amination reagent has a structure as shown in a formula disclosed in the invention, wherein Xis selected from any one of I, Cl, Br, NO3 and ClO4, and Y and Z are independently selected from H or alkyl with the carbon atom number of 1-4. The process for preparing the amination reagent is simple, the raw materials are easy to obtain, the cost is low, the yield is stable, and the prepared amination reagent is stable in character, can be stored at room temperature for a long time and can be taken as needed; meanwhile, the prepared amination reagent is efficient in performance, boron substrate applicability is excellent, reaction effect is good, and limitation of amination reaction of organic boron compounds on substrates is greatly expanded.

Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: From potent activators to highly efficient inhibitors

In this study, we developed 3-/4-aminoacetophenones and their structure-based 3-/4-aminophenylethylidenethiosemicarbazide derivatives, respectively, as novel tyrosinase activators and inhibitors. Notably, all the obtained thiosemicarbazones displayed more potent tyrosinase inhibitory activities than kojic acid. Especially, compound 7k was found to be the most active tyrosinase inhibitor with IC50 value of 0.291 1/4M. The structure-activity relationships (SARs) analysis showed that: (1) the amine group was absolutely necessarily for determining the tyrosinase activation activity; (2) the introduction of thiosemicarbazide group played a very vital role in transforming tyrosinase activators into tyrosinase inhibitors; (3) the phenylethylenethiosemicarbazide moiety was crucial for determining the tyrosinase inhibitory activity; (4) the type of acyl group had no obvious effect on the inhibitory activity; (5) the position of amide substituent on the phenyl ring influenced the tyrosinase inhibitory potency. Moreover, the inhibition mechanism and inhibition kinetics study revealed that compound 7k was reversible and non-competitive inhibitor, and compound 8h was reversible and competitive-uncompetitive mixed-II type inhibitor.

Copper-catalyzed synthesis of primary arylamines from aryl halides and 2,2,2-trifluoroacetamide

A catalytic method was developed to synthesize primary arylamines from the corresponding aryl bromides and iodides under mild conditions (yields = 80-99%). Crystalline 2,2,2-trifluoroacetamide was used as ammonia surrogate and CuI/N,N′-dimethyl ethylenediamine was used as catalyst to achieve the C-N cross-coupling.