366-63-2

Basic information

• Product Name: 4-fluorobenzanilide
• Synonyms: 4-fluorobenzanilide;N-Phenyl-4-fluorobenzamide;N-Phenyl-p-fluorobenzamide
• CAS NO: 366-63-2
• Molecular Formula: C₁₃H₁₀FNO
• Molecular Weight: 215.2230032
• EINECS: 206-677-0
• Mol File: 366-63-2.mol
• Article Data: 90

Chemical Properties

• Melting Point: 182-184 °C
• Boiling Point: 258.1°Cat760mmHg
• Flash Point: 109.9°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.622
• PKA: 13.39±0.70(Predicted)
• CAS DataBase Reference: 4-fluorobenzanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluorobenzanilide(366-63-2)
• EPA Substance Registry System: 4-fluorobenzanilide(366-63-2)

Safety Data

• Hazardous Substances Data: 366-63-2(Hazardous Substances Data)

Usage

General Description

4-Fluorobenzanilide, also known as 4-fluoro-N-phenylbenzamide, is an organic compound that consists of a fluorine atom attached to a benzene ring, and an amide group bonded to the phenyl ring. It is a white solid that is sparingly soluble in water but dissolves in organic solvents. 4-Fluorobenzanilide is commonly used as an intermediate in the production of pharmaceuticals and other organic compounds. It has also been studied for its potential use in organic synthesis and medicinal chemistry applications. Additionally, it has been investigated for its potential pharmacological properties, including its role as a potential analgesic or anti-inflammatory agent.

InChI:InChI=1/C13H10FNO/c14-11-8-6-10(7-9-11)13(16)15-12-4-2-1-3-5-12/h1-9H,(H,15,16)

Upstream product

• 824-75-9 p-fluorobenzamide 
• 603-33-8 triphenylbismuthane 
• 456-22-4 4-Fluorobenzoic acid 
• 62-53-3 aniline 
• 362-99-2 (4-fluorophenyl)phenylmethanone oxime 
• 403-43-0 4-fluorobenzoyl chloride 
• 362-99-2 (4-fluorophenyl)-phenylmethanone oxime 
• 30114-44-4 para-fluorophenyl formate 
• 2714-90-1 phenyl 4-fluorobenzoate 
• 136138-52-8 4-fluoro-N-(2-iodophenyl)benzamide 
• 459-56-3 4-fluorobenzylic alcohol 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 79606-49-8 N,N-diphenyl-p-fluorobenzamide 
• 459-56-3 4-fluorobenzylic alcohol 
• 62-53-3 aniline 
• 345-83-5 4-fluorobenzophenone 
• 1629-26-1 2-(4-fluorophenyl)-benzothiazole 
• 1629-19-2 N-(4-Fluor-thiobenzoyl)-anilin 
• 83444-25-1 N-(p-fluorobenzyl)aniline 
• 100-51-6 benzyl alcohol 
• 1233731-18-4 5-(4-fluorophenyl)-1-phenyl-1H-tetrazole 
• 782-17-2 2-(4-fluorophenyl)indole 
• 1978-65-0 4-(4-fluorobenzoyl)morpholine 
• 2647-04-3 N-(4-fluorophenyl)-2-phenylpropanamide 
• 33489-70-2 4-fluoro-N-(4-methoxyphenyl)benzamide 

Relevant articles and documents

Design, Synthesis, and Pharmacological Activity of a New Matrix Metalloproteinase-9 Inhibitor

The new MMP-9 inhibitor 1-{4-[(4-chlorobenzoyl)amino]phenyl}sulfonyl-L-proline, with a theoretical inhibition constant of IC50 = 4 × 105 M, was constructed on the basis of structural requirements for selective inhibitors of gelatinases. This constructed compound and its close structural analogs were synthesized and these substances were found to have low toxicity, (LD50 > 300 mg/kg). The new inhibitor given p.o. at a dose of 20 mg/kg/day on the background of acute myocardial infarction significantly decreased the content of immunoreactive MMP-9 in plasma in rats, to the level obtained with doxycycline.

Exploration of Cu-catalyzed regioselective hydrodehalogenation of o-haloanilides using EtOH as hydrogen source

In present work, we have explored a Cu(acac)2/vasicine-catalyzed regioselective hydrodehalogenation methodology of o-haloanilides using EtOH as hydrogen source and solvent. The catalytic system could selectively dehalogenate 2-Br and 2-I, and features regioselective, efficient and functional group tolerance.

Visible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions

A metal-free heterogeneous photocatalysis has been developed for the synthesis of benzothiazoles via intramolecular C-H functionalization/C-S bond formation of thiobenzanilides by inexpensive graphitic carbon nitride (g-C3N4) under visible-light irradiation. This reaction provides access to a broad range of 2-substituted benzothiazoles in high yields under an air atmosphere at room temperature without addition of a strong base or organic oxidizing reagents. In addition, the catalyst was found to be stable and reusable after five reaction cycles.