60-15-1

Basic information

• Product Name: alpha-methylphenethylamine
• Synonyms: 3-Phenyl-2-propylamine;1-Phenyl-2-propanamine;2-Aminopropylbenzene;3-Phenyl-2-propanamine
• CAS NO: 60-15-1
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 0
• EINECS: 200-458-3
• Mol File: 60-15-1.mol
• Article Data: 68

Chemical Properties

• Boiling Point: 234.7°C at 760 mmHg
• Flash Point: 98.7°C
• Appearance: /
• Density: 0.958g/cm³
• Vapor Pressure: 0.0521mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: alpha-methylphenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-methylphenethylamine(60-15-1)
• EPA Substance Registry System: alpha-methylphenethylamine(60-15-1)

Safety Data

• Hazardous Substances Data: 60-15-1(Hazardous Substances Data)

Usage

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Human systemic effects by ingestion: excitement, changesin heart rate and sweating. When heated to decompositionit emits very toxic fumes of NOx. See other amphetamineentries.

InChI:InChI=1/C9H13N/c1-2-4-8-5-3-6-9(10)7-8/h3,5-7H,2,4,10H2,1H3

Upstream product

• 17019-26-0 (E)-2-(hydroxyimino)-1-phenylpropan-1-one 
• 156-34-3 l-amphetamine 
• 5171-99-3 (1-phenylpropan-2-ylidene)hydrazine 
• 7499-19-6 2-methyl-2-phenylpropionamide 
• 10304-81-1 1-phenyl-2-chloropropane 
• 55-52-7 pheniprazine 
• 81136-08-5 2-methyl-3-phenylpropanoyl chloride 
• 14593-16-9 N-acetylamphetamine 
• 77287-34-4 formamide 
• 103-79-7 1-phenyl-acetone 
• 13213-36-0 1-phenylpropan-2-one oxime 
• 98-71-5 4-hydrazino-benzenesulfonic acid 
• 540-69-2 ammonium formate 
• 705-60-2 (2-nitroprop-1-enyl)benzene 

Downstream Products

• 26393-84-0 bis-(2-hydroxy-ethyl)-(1-methyl-2-phenyl-ethyl)-amine 
• 63918-85-4 2-(1-methyl-2-phenyl-ethylamino)-ethanol 
• 20640-10-2 N-(1-Methyl-2-phenyl-ethyl)-β-mercapto-ethylamin 
• 108303-14-6 N-(1-methyl-2-phenyl-ethyl)-ethylenediamine 
• 105340-05-4 1-(1-methyl-2-phenyl-ethyl)-imidazolidin-2-one 
• 139-68-4 (+/-)-nicotinic acid-(1-methyl-2-phenyl-ethylamide) 
• 15855-02-4 N-α-Methylphenethyl-n-pyridincarboxamid 
• 93315-98-1 2-(1-methyl-2-phenylethyl)-1H-isoindole-1,3(2H)-dione 
• 3319-00-4 (+/-)-1-(1-methyl-2-phenylethyl)piperidine 
• 100369-88-8 optically inactive N-(1-methyl-2-phenyl-ethyl)-lactamide 
• 4106-13-2 optically inactive N,N'-bis-(1-methyl-2-phenyl-ethyl)-urea 
• 102757-99-3 (1-methyl-2-phenyl-ethyl)-(1-methyl-4-phenyl-[4]piperidylmethylen)-amine 
• 21502-12-5 (+/-)-dichloroacetic acid-(1-methyl-2-phenyl-ethylamide) 
• 51-64-9 dexamfetamine 

Relevant articles and documents

Rapid Synthesis of Primary Amines from Ketones using Choline Chloride/Urea Deep Eutectic as a Reaction Medium

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ASPARAGINE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to compounds of formulas (A) and (I), pharmaceutically acceptable salts thereof, and solvates of any of them, pharmaceutical compositions comprising them, methods of preparation thereof, intermediate compounds useful for the preparation thereof, and methods of treatment or prophylaxis of diseases, in particular cancer, such as colorectal cancer, using these. (A) (I)

Transaminase-mediated synthesis of enantiopure drug-like 1-(3′,4′-disubstituted phenyl)propan-2-amines

Transaminases (TAs) offer an environmentally and economically attractive method for the direct synthesis of pharmaceutically relevant disubstituted 1-phenylpropan-2-amine derivatives starting from prochiral ketones. In this work, we report the application of immobilised whole-cell biocatalysts with (R)-transaminase activity for the synthesis of novel disubstituted 1-phenylpropan-2-amines. After optimisation of the asymmetric synthesis, the (R)-enantiomers could be produced with 88-89% conversion and >99% ee, while the (S)-enantiomers could be selectively obtained as the unreacted fraction of the corresponding racemic amines in kinetic resolution with >48% conversion and >95% ee. This journal is