609-85-8

Basic information

• Product Name: 2-Amino-3,5-dibromobenzoic acid
• Synonyms: Benzoic acid, 2-amino-3,5-dibromo-;RARECHEM AL BO 1185;BUTTPARK 89\07-50;3,5-DIBROMOANTHRANILIC ACID;3,5-DIBROMO-2-AMINOBENZOIC ACID;2-AMINO-3,5-DIBROMOBENZOIC ACID;2-Amino-3,5-dibromobenzoic acid, tech;3,5-DIBROMOANTHRANILIC ACID, 98+%
• CAS NO: 609-85-8
• Molecular Formula: C₇H₅Br₂NO₂
• Molecular Weight: 294.93
• EINECS: 1533716-785-6
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Acids & Esters;Anilines, Amides & Amines;Bromine Compounds;Aromatic Amino Acids;Unnatural Amino Acid Derivatives;Peptide Synthesis
• Mol File: 609-85-8.mol
• Article Data: 31

Chemical Properties

• Melting Point: 235-236 °C(lit.)
• Boiling Point: 367.6 °C at 760 mmHg
• Flash Point: 176.1 °C
• Appearance: White to beige/Powder
• Density: 2.158 g/cm³
• Vapor Pressure: 4.74E-06mmHg at 25°C
• Refractive Index: 1.699
• PKA: 4.16±0.10(Predicted)
• BRN: 779291
• CAS DataBase Reference: 2-Amino-3,5-dibromobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3,5-dibromobenzoic acid(609-85-8)
• EPA Substance Registry System: 2-Amino-3,5-dibromobenzoic acid(609-85-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-37/38-36
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 609-85-8(Hazardous Substances Data)

Usage

Synthesis

A solution of bromine (7.2 g, 2 mL, 40 mmol) in 47 mL glacial acetic acid was added dropwise to sodium 2-aminobenzoate (6.4 g, 40 mmol) in 32 mL of glacial acetic acid ?at 15 °С and the mixture was stirred for 1 h at the same temperature. The product ?was filtered off, washed with benzene and dried in the dark. The bromobenzoic acids ?containing mixture (0.5 g) was added to 10 mL of boiling water followed by the ?addition of 1.3 mL of concentrated hydrochloric acid and hot filtration under vacuum. ?The insoluble material contained 2-amino-3,5-dibromobenzoic acid, whereas 2- amino-5-bromobenzoic acid precipitated upon cooling of the filtrate.?IR (suspension in nujol, cm?1 ): 3469, 3364, ?1682, 1600, 1564, 1538, 1454, 1421, 1378, 1328, 1307, 1226, 1063, 902, 882, 790, ?711, 691, 591, 543.

Chemical Properties

White to light yellow crystal powder

InChI:InChI=1/C7H5Br2NO2/c8-3-1-4(7(11)12)6(10)5(9)2-3/h1-2H,10H2,(H,11,12)

Upstream product

• 40889-42-7 6,8-dibromo-2-methyl-3,1-benzoxazin-4(H)-one 
• 88-72-2 1-methyl-2-nitrobenzene 
• 118-92-3 anthranilic acid 
• 2299-73-2 N,N-bis(4-methoxybenzylidene)hydrazine 
• 28867-76-7 benzaldehyde benzylidenehydrazone 
• 95-54-5 1,2-diamino-benzene 
• 54754-60-8 6-chloro-8-methyl-1H-3,1-benzoxazine-2,4-dione 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 89-52-1 o-acetylamino-benzoic acid 
• 76435-23-9 2-Nitro-3,5-dibromtoluen 
• 552-37-4 sodium o-aminobenzoate 
• 2439-85-2 N-bromophthalimide 
• 50910-55-9 3,5-dibromo-2-amino benzaldehyde 

Downstream Products

• 40889-42-7 6,8-dibromo-2-methyl-3,1-benzoxazin-4(H)-one 
• 17518-85-3 6,8-dibromo-3,4-dihydro-4-oxo-quinazoline 
• 643-37-8 6,8-dibromoquinazoline-2,4-(1H,3H)-dione 
• 54754-60-8 6-chloro-8-methyl-1H-3,1-benzoxazine-2,4-dione 
• 618-58-6 3,5-dibromobenzoic acid 
• 6311-60-0 3,5-dibromonitrobenzene 
• 615-57-6 2,4-dibromo-aniline 
• 15719-64-9 methylammonium carbonate 
• 15396-38-0 2,3,5-tribromo-benzoic acid 
• 16524-04-2 2‐amino‐3,5‐dibromobenzamide 
• 15396-40-4 3,5-dibromo-2-iodo-benzoic acid 
• 114571-71-0 3,5-dibromo-phthalic acid 
• 58155-85-4 6,8-dibromo-2-styryl-benzo[d][1,3]oxazin-4-one 
• 73314-26-8 6,8-dibromo-2-(3,4,5-trimethoxy-phenyl)-benzo[d][1,3]oxazin-4-one 

Relevant articles and documents

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Method of catalytically synthesizing polybromo-aniline in water phase

The invention discloses a method of catalytically synthesizing polybromo-aniline in a water phase. The method comprises following steps: adding a catalytic amount of a free radical initiator, aniline derivatives, cheap and low-toxic bromine salts, and water into a reactor; carrying out reactions in a photocatalytic reaction instrument under power of 5W at a room temperature; after a while, extracting the reaction product by ethyl acetate, and carrying out recrystallization to obtain polybromo-aniline; wherein the free radical initiator is eosin, sodium persulfate, or potassium persulfate. The power of the incandescent lamp of the photocatalytic reaction instrument is 5W. The free radical initiator and bromine salts are cheap and easily available. The method is an ideal synthesis method of polybromo-aniline. Cheap and low-toxic bromine salts are used to replace liquid bromine. The cheap and easily available free radical initiator is used to replace unstable and explosive hydrogen peroxide. After 4 to 10 hours of reactions under the power of 5W, polybromo-aniline can be synthesized, the yield and the reaction selectivity are high, the byproducts are few, and the post treatment is simple.

Preparation method for ambroxol hydrochloride intermediate 3,5-dibromo-2-aminobenzoic acid

The invention discloses a preparation method for an ambroxol hydrochloride intermediate 3,5-dibromo-2-aminobenzoic acid. The method enables the ambroxol hydrochloride intermediate 3,5-dibromo-2-aminobenzoic acid to be obtained through the following two-st