621-40-9

Basic information

• Product Name: 1-(3-METHYLPHENYL)-2-THIOUREA
• Synonyms: N-(3-METHYLPHENYL)THIOUREA;M-TOLYL-THIOUREA;(3-methylphenyl)-thioure;(3-methylphenyl)thiourea;1-(m-methylphenyl)thiourea;1-m-tolylthiourea;2-thio-1-m-tolyl-ure;3-tolylthiourea
• CAS NO: 621-40-9
• Molecular Formula: C₈H₁₀N₂S
• Molecular Weight: 166.24
• EINECS: 210-686-5
• Mol File: 621-40-9.mol
• Article Data: 26

Chemical Properties

• Melting Point: 120-122°C
• Boiling Point: 280.7 °C at 760 mmHg
• Flash Point: 123.6 °C
• Appearance: /
• Density: 1.242 g/cm³
• Vapor Pressure: 0.00373mmHg at 25°C
• Refractive Index: 1.696
• PKA: 13.15±0.70(Predicted)
• CAS DataBase Reference: 1-(3-METHYLPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-METHYLPHENYL)-2-THIOUREA(621-40-9)
• EPA Substance Registry System: 1-(3-METHYLPHENYL)-2-THIOUREA(621-40-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 621-40-9(Hazardous Substances Data)

Usage

General Description

1-(3-Methylphenyl)-2-thiourea is a chemical compound with the molecular formula C8H10N2S. It is a thiourea derivative, which is a type of organic compound containing a sulfur atom attached to a carbon atom in the molecule. The compound has a molecular weight of 166.25 g/mol and a melting point of 165-168°C. 1-(3-Methylphenyl)-2-thiourea is commonly used in organic synthesis and medicinal chemistry, and it has been studied for its potential pharmacological properties, such as antitumor and antifungal activities. It is also used as a reagent in chemical reactions and as a building block in the synthesis of various organic compounds.

InChI:InChI=1/C8H10N2S/c1-6-3-2-4-7(5-6)10-8(9)11/h2-5H,1H3,(H3,9,10,11)

Upstream product

• 621-30-7 3-methylphenyl isothiocyanate 
• 1147550-11-5 ammonium thiocyanate 
• 638-03-9 m-toluidine hydrochloride 
• 540-72-7 sodium thiocyanide 
• 108-44-1 1-amino-3-methylbenzene 
• 17356-08-0 thiourea 
• 620-51-9 N,N'-di(3-methylphenyl)thiourea 
• 60-29-7 diethyl ether 
• 7664-41-7 ammonia 
• 4949-87-5 N-benzoyl-N′-(3-methylphenyl)thiourea 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 27052-16-0 2-(3-tolylimino)-1,3-thiazol-4-one 
• 25364-30-1 3-[4-methyl-2-(3-methyl-anilino)-thiazol-5-yl]-chromen-2-one 
• 23993-30-8 4-amino-2-imino-3-m-tolyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 94206-89-0 5-(4-chloro-phenyl)-2-(3-methyl-anilino)-thiazol-4-one 
• 65069-77-4 2-Methyl-1-m-tolyl-isothiourea; hydriodide 
• 65069-77-4 methyl N-(3-methylphenyl)imidothiocarbamate hydroiodide 
• 260243-56-9 5-amino-4-oxo-2-m-tolylimino-thiazolidine-5-carboxylic acid ethyl ester 
• 55591-33-8 3-methylphenylcyanamide 
• 127251-89-2 4,6-Dimethyl-1-m-tolyl-1H-pyrimidine-2-selone 
• 127251-59-6 C₁₄H₁₇N₂S⁽¹⁺⁾*CH₃O₄S^(1-) 
• 23996-40-9 1-(3-methylphenyl)-4,5-diphenyl-1,3-dihydroimidazole-2-thione 
• 27052-16-0 C₁₀H₁₀N₂OS 
• 944548-96-3 4-hydroxy-3-(2-m-tolylamino-thiazol-4-yl)chromen-2-one 
• 1202801-17-9 N-(3-methylphenyl)-4-(3-pyridinylmethyl)-1,3-thiazol-2-amine 

Relevant articles and documents

Green and efficient synthesis of thioureas, ureas, primary: O -thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(ii) chloride [ChCl][SnCl2]2 with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against: Klebsiella pneumoniae

A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712). Some of the synthesized compounds exhibited synergistic activity. When 4 μg ml-1 compound B1 was combined with PB, it showed potent antibacterial activity, achieving 64-fold reduction of the MIC of PB. Furthermore, compound B1 showed prominent synergistic efficacy in both concentration gradient and time-kill curves in vitro. In addition, B1 combined with PB also exhibited synergistic and partial synergistic effect against E. coli (ATCC25922 and its clinical isolates), Acinetobacter baumannii (ATCC19606 and its clinical isolates), and Pseudomonas aeruginosa (Pae-1399).

A thiazolidine compound of ketones, and its preparation for treating iron disorder related disease application of the medicament (by machine translation)

The invention discloses a thiazolidone compound, wherein a chemical structure of the thiazolidone compound is shown in a general form (I). The invention also discloses application of the thiazolidone compound in preparation of a medicine used for treating thalassemia. Experiments prove that the thiazolidone compound can be used for effectively stimulating expression of hepcidin in cells under the condition that concentration is 10mu M, can be still used for effectively inducing expression of hepcidin in liver when being exposed for 6 hours, 24 hours and 48 hours respectively at a dosage of 30mg/kg in animal level and can be also used for effectively reducing level of serum iron, so that the thiazolidone compound can take hepcidin as a target, can be used for reducing iron level in serum, is hopeful to be a potential medicine used for treating and alleviating iron disorder-related diseases and has a broad clinical application prospect and a great economic development value.