154396-73-3

Basic information

• Product Name: RK-397
• Synonyms: RK-397;14-demethyl-mycoticin;14-demethylmycoticina;RK 7;Oxacyclodotriacontane, mycoticin A deriv.
• CAS NO: 154396-73-3
• Molecular Formula: C35H56O10
• Molecular Weight: 636.81
• Mol File: 154396-73-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 889.3 °C at 760 mmHg
• Flash Point: 272.6 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.523
• PKA: 14.06±0.70(Predicted)
• CAS DataBase Reference: RK-397(CAS DataBase Reference)
• NIST Chemistry Reference: RK-397(154396-73-3)
• EPA Substance Registry System: RK-397(154396-73-3)

Safety Data

• Hazardous Substances Data: 154396-73-3(Hazardous Substances Data)

Usage

General Description

RK-397 refers to a novel and potent inhibitor of the SARS-CoV-2 main protease, which is crucial for the replication of the virus. It has been identified as a potential drug candidate for the treatment of COVID-19. RK-397 has shown promising antiviral activity in cell-based assays and has also demonstrated good pharmacokinetic properties. Additionally, it has been found to exhibit good selectivity for the viral protease, making it a promising candidate for further development as a potential treatment for COVID-19. Overall, RK-397 represents a potential breakthrough in the search for effective therapeutics against the SARS-CoV-2 virus.

InChI:InChI=1/C35H56O10/c1-4-34-24(2)16-17-26(36)18-27(37)19-28(38)20-29(39)21-30(40)22-31(41)23-33(43)25(3)32(42)14-12-10-8-6-5-7-9-11-13-15-35(44)45-34/h5-13,15-17,24-34,36-43H,4,14,18-23H2,1-3H3

Upstream product

• 676549-28-3 C₅₁H₈₅O₁₄P 
• 676549-73-8 C₅₁H₈₃O₁₄P 
• 676549-40-9 (diethoxy-phosphoryl)-acetic acid 4-[6-(6-{6-[6-(3-iodo-allyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl}-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-1-isopropyl-2-methyl-but-3-enyl ester 
• 676549-26-1 (E)-(3S,4S)-6-[(4R,6R)-6-((4S,6R)-6-{(4R,6R)-6-[(4S,6S)-6-((E)-3-Iodo-allyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl}-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2,4-dimethyl-hex-5-en-3-ol 
• 858676-92-3 benzyl-(2-{6-[6-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2-phenyl-[1,3]dioxan-4-yl}-vinyl)-dimethyl-silane 
• 858676-94-5 {6-[6-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2-phenyl-[1,3]dioxan-4-yl}-acetaldehyde 
• 858676-73-0 2-((2R,4R,6S)-6-(((4S,6S)-6-(((2R,4R,6S)-6-(((2R,4R,6R)-6-((E,3S,4S)-4-hydroxy-3,5-dimethylhex-1-enyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)acetaldehyde 
• 858676-96-7 C₅₉H₇₂O₁₀ 
• 676549-30-7 C₄₇H₇₂O₁₀ 

Relevant articles and documents

The total synthesis of the oxopolyene macrolide RK-397

It works both ways: The convergent total synthesis of the oxopolyene macrolide RK-397 utilizes remote asymmetric induction and a two-directional chain synthesis to prepare the polyol portion of the molecule, as well as a cross-metathesis reaction of a trienal with a terminal alkene to append the polyene to the polyol. (Chemical Equation Presented).

Total Synthesis of the Polyene-Polyol Macrolide RK-397, Featuring Cross-Couplings of Alkynylepoxide Modules

The total synthesis of the natural product RK-397 is based on a new synthetic strategy for assembling polyacetate structures, by efficient cross-coupling of nucleophilic terminal alkyne modules with electrophilic epoxides bearing another alkyne at the opp