5471-96-5

Basic information

• Product Name: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE
• Synonyms: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE
• CAS NO: 5471-96-5
• Molecular Formula: C₁₅H₁₀Br₂O
• Molecular Weight: 366.05
• Mol File: 5471-96-5.mol
• Article Data: 55

Chemical Properties

• Boiling Point: 450.6°C at 760 mmHg
• Flash Point: 131.2°C
• Appearance: /
• Density: 1.647g/cm³
• Vapor Pressure: 2.6E-08mmHg at 25°C
• Refractive Index: 1.664
• CAS DataBase Reference: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE(5471-96-5)
• EPA Substance Registry System: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE(5471-96-5)

Safety Data

• Hazardous Substances Data: 5471-96-5(Hazardous Substances Data)

Usage

Description

1,3-BIS-(4-BROMO-PHENYL)-PROPENONE, also known as dibromobenzylideneacetone, is a chemical compound with the molecular formula C15H11Br2O. It is a yellow to brown crystalline solid that is highly flammable and considered harmful if swallowed, inhaled, or if it comes into contact with the skin or eyes. 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE is commonly used as a precursor in the synthesis of various pharmaceutical and agrochemical compounds.

Uses

Used in Pharmaceutical Industry:
1,3-BIS-(4-BROMO-PHENYL)-PROPENONE is used as a precursor in the synthesis of various pharmaceutical compounds for its ability to be chemically modified and incorporated into the structure of target drugs.
Used in Agrochemical Industry:
1,3-BIS-(4-BROMO-PHENYL)-PROPENONE is used as a precursor in the synthesis of various agrochemical compounds for its potential to be transformed into active ingredients for pesticides or other agricultural products.
Safety Precautions:
When handling and storing 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE, it is essential to take proper safety measures due to its flammable nature and potential to cause harm if not handled correctly. This includes using appropriate personal protective equipment, such as gloves, goggles, and respirators, to minimize the risk of skin and eye irritation or inhalation. Additionally, it should be stored in a well-ventilated area away from heat and open flames to prevent accidental ignition.

InChI:InChI=1/C15H10Br2O/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10H/b10-3+

Upstream product

• 99-90-1 para-bromoacetophenone 
• 1122-91-4 4-bromo-benzaldehyde 
• 99-73-0 para-bromophenacyl bromide 
• 5471-96-5 (E)-1,3-bis(4-bromophenyl)prop-2-en-1-one 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 1777-57-7 p-bromobenzoylmethylenetriphenylphosphorane 

Downstream Products

• 494764-44-2 3,5-Bis-(4-bromo-phenyl)-4,5-dihydro-1H-pyrazole 
• 107553-45-7 2,4-Bis-(4-bromo-phenyl)-benzo[4,5]imidazo[1,2-a]pyrimidine 
• 61595-99-1 3-(4-bromophenyl)-5-(4-bromophenyl)-1-phenyl-2-pyrazoline 
• 65662-66-0 (cis)-1,2-Bis(p-bromophenyl)cyclopropane 
• 34733-66-9 (trans)-1,2-Bis(p-bromophenyl)cyclopropane 
• 77172-40-8 (trans)-1,2-Bis(p-cyanophenyl)cyclopropane 
• 1234016-37-5 C₂₄H₁₇Br₂N₃S 
• 1333466-19-5 C₁₆H₁₃Br₂N₃S 
• 1332363-36-6 (3S,4S)-4,6-bis(4-bromophenyl)-3-(3-oxo-3-phenylpropyl)-3,4-dihydro-2H-pyran-2-one 
• 1356835-16-9 C₂₆H₁₉Br₂N₇O 
• 1366267-88-0 2-(3,5-bis(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one 
• 1226780-87-5 2-amino-4-(4-bromophenyl)-6-(4-bromophenyl)pyrimidine 
• 1400673-91-7 2-(3,5-bis(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-5-bromopyrimidine 
• 1415465-98-3 6-bromo-2-(4-bromophenyl)-3,3a-dihydropyrazolo[5,1-a]isoindol-8-one 

Relevant articles and documents

A π-Conjugated, Covalent Phosphinine Framework

Structural modularity of polymer frameworks is a key advantage of covalent organic polymers, however, only C, N, O, Si, and S have found their way into their building blocks so far. Here, the toolbox available to polymer and materials chemists is expanded

Chemoselective reduction of α,β-unsaturated carbonyl compounds in the presence of CuPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as highly efficient catalyst

Herein, we reported reductions of acid, amide, ester and ketone groups with selectivity (>99%) by the catalytic transfer hydrogenation of with CuPd alloy nanoparticles (NPs) decorated on mesoporous graphitic carbon nitride (Cu50Pd50/mpg-C3N4) catalyst under mild conditions in a water/methanol mixture. CuPd alloy NPs were synthesized by the co-reduction of palladium (II) acetylacetonate and copper(II) acetylacetonate in oleylamine (OAm) solution by the reduction of morpholine-borane solution and then assembled on mpg-C3N4 via liquid phase self‐assembly method. The α, β-unsaturated carbonyl compounds were obtained from the condensation reaction of the benzaldehyde derivatives with acetone derivatives. Cu50Pd50/mpg-C3N4 nanocatalyst was characterized by TEM, XRD, XPS, BET and ICP‐MS. Cu50Pd50/mpg-C3N4 nanocatalyst is highly active catalyst for the reduction of various organic groups and converted to high yield and 99% selectivity. The superior Cu50Pd50/mpg-C3N4 nanocatalyst is highly efficient and reusable catalyst which is reuse after 5 cycle with 98% conversion.

Catalyst- and acid-free Markovnikov hydration of alkynes in a sustainable H2O/ethyl lactate system

An efficient and sustainable protocol for the hydration of alkynes has been developed under metal/acid/catalyst/ligand-free conditions in a water/ethyl lactate mixture. The hydrogen-bond network in the ethyl lactate and water mixture plays a crucial and decisive role in activating the alkynes for hydration to afford the corresponding methyl ketones. This strategy gives the Markovnikov (ketone) addition product selectively over other possible products. The essential role of hydrogen bonding has been confirmed by experimental and theoretical techniques. A probable mechanism has been suggested by various control tests. The efficacy of the method has been further explored for the competent production of value-added α,β-unsaturated carbonyl compounds through the reaction of aldehydes with alkynes as ketonic surrogates. The environmentally benign hydration method takes place under mild conditions, has broad functional-group compatibility, and uses the ethyl lactate/water (1:3) medium as a “green alternative” in the absence of any hazardous, harmful, or expensive substances.

Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis

Systemic inflammatory response syndrome is a major feature of sepsis which is one of the major causes of death worldwide. It has been reported that 3,5-diaryl-4,5-dihydropyrazole and thiazole derivatives have many biological functions, especially in the aspect of anti-inflammation. According to the strategy of pharmacophore combination, we introduced thiazole moiety into dihydropyrazole skeleton to design and synthesize a novel series of 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-methylthiazole derivatives, and evaluated their anti-inflammatory activities for sepsis treatment. Preliminary structure?activity relationship (SAR) analysis was conducted by their inhibitory activities against nitric oxide (NO) release in LPS-induced RAW264.7 cells, and the optimal compound E26 exhibited more potent anti-inflammatory activity than the positive control treatment indomethacin and dexamethasone. In further mechanism study, our results showed that compound E26 significantly suppressed the production of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), NO and inhibited the expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) through blocking MAPKs signaling pathway. In addition, in vivo administration of compound E26 resulted in a significant improvement of LPS-induced sepsis in C57BL/6J mice, with reducing toxicity in multiple organs. Taken together, this study demonstrated the compound E26 could be a promising agent for the treatment of sepsis.