82408-64-8

Basic information

• Product Name: N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine
• Synonyms: N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine
• CAS NO: 82408-64-8
• Molecular Weight: 194.233
• Mol File: 82408-64-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine(82408-64-8)
• EPA Substance Registry System: N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine(82408-64-8)

Safety Data

• Hazardous Substances Data: 82408-64-8(Hazardous Substances Data)

Upstream product

• 1197-21-3 phentermine hydrochloride 
• 34405-42-0 α-(1-amino-1-methylethyl)benzenemethanol 
• 33687-74-0 1-phenyl-2-methyl-2-nitropropanol 
• 100-52-7 benzaldehyde 
• 26187-18-8 2-chloro-N-(2-methyl-1-phenylpropan-2-yl)acetamide 
• 100-86-7 2-Methyl-1-phenyl-2-propanol 
• 122-09-8 Phentermin 

Downstream Products

• 454219-02-4 [2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine 
• 454219-23-9 N'-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]-2-methylpropyl]phenyl]-N,N-dimethyl-sulfamide 
• 454219-03-5 4-{2(R)-[2-(tert-butyl-dimethyl-silanyloxy)-2-pyridin-3-yl-ethylamino]-2-methyl-propyl}-phenylamine 
• 454219-32-0 N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]-2-methylpropyl]phenyl]-N'-(2-methoxyethyl)-sulfamide 
• 454219-22-8 N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]-2-methylpropyl]phenyl]-N'-phenyl-sulfamide 
• 454219-16-0 N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]-2-methylpropyl]phenyl]-4-methyl-1-piperidinesulfonamide 
• 454219-15-9 N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-2,6-dimethyl-,(2R,6S)-4-morpholinesulfonamide 
• 454219-17-1 N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-3,5-dimethyl-, (3R,5S)-1-piperidinesulfonamide 
• 51131-55-6 4-(β-amino-isobutyl)-aniline 
• 454218-98-5 1(R)-(3-chloro-phenyl)-2-[1,1-dimethyl-2-(4-nitro-phenyl)-ethylamino]-ethanol 
• 180081-15-6 tert-butyl N-[2-methyl-1-(4-nitrophenyl)-2-propyl]carbamate 
• 1198312-16-1 C₂₁H₂₇N₃O₆S 
• 1198312-18-3 C₂₁H₂₉N₃O₄S 
• 1357290-70-0 KMI-1717 

Relevant articles and documents

Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof

Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.

A multivalent approach to the discovery of long-acting β2- adrenoceptor agonists for the treatment of asthma and COPD

A multivalent approach was applied to the design of long-acting inhaled β2-adrenoceptor agonists. A series of dimeric arylethanolamines based on the short acting β2-adrenoceptor agonist albuterol were prepared, varying the nature and length of the linker between the basic nitrogens. None of the C2-symmetric dimers demonstrated increased potency, however dimer 5j, derived from 4-phenethylamine, was found to have increased binding potency in vitro relative to the parent monomer. Optimization of this structure led to the identification of 22 (milveterol) which demonstrates high potency in vitro and long duration of action in a guinea pig model of bronchoprotection.

Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists

This Letter describes optimization of ghrelin receptor antagonists and inverse agonists starting from a screening hit.