15862-72-3 Usage
Description
Ethyl pipecolinate is a clear colorless to light yellow liquid that serves as a versatile reactant in various chemical processes and applications. It is known for its ability to participate in combinatorial chemistry with hydrazones, swift hydroamination, and other reactions that contribute to the synthesis of various compounds and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
Ethyl pipecolinate is used as a reactant for the synthesis of HCV NS5B polymerase inhibitors, which are crucial in the development of treatments for Hepatitis C virus. Its role in this application is to facilitate the creation of compounds that can effectively inhibit the replication of the virus.
Used in Chemical Research:
In the field of chemical research, ethyl pipecolinate is used as a reactant for combinatorial chemistry with hydrazones. This application allows for the exploration of new chemical reactions and the discovery of novel compounds with potential applications in various industries.
Used in the Synthesis of Selective Androgen Receptor Modulators:
Ethyl pipecolinate is utilized as a reactant in the preparation of selective androgen receptor modulators, which are important in the development of treatments for conditions related to androgen receptor function, such as muscle wasting, osteoporosis, and certain types of cancer.
Used in the Synthesis of Quinoline Derivatives:
Ethyl pipecolinate is used as a reactant in the synthesis of quinoline derivatives, which serve as selective a2C-adrenoceptor antagonists. These compounds have potential applications in the treatment of various conditions, including hypertension and other cardiovascular diseases.
Used in Decarbonylative Arylation at sp3 Carbon Centers:
Ethyl pipecolinate is employed as a reactant in decarbonylative arylation at sp3 carbon centers, a chemical process that allows for the formation of new carbon-carbon bonds and the synthesis of complex organic molecules with potential applications in various industries, including pharmaceuticals and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 15862-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,8,6 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15862-72:
(7*1)+(6*5)+(5*8)+(4*6)+(3*2)+(2*7)+(1*2)=123
123 % 10 = 3
So 15862-72-3 is a valid CAS Registry Number.
15862-72-3Relevant articles and documents
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Clemo,Ramage
, p. 437,441 (1931)
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Gallop et al.
, p. 2409,2429 (1968)
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Development, synthesis and structure–activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei
Seufert, Florian,Kuhn, Maximilian,Hein, Michael,Weiwad, Matthias,Vivoli, Mirella,Norville, Isobel H.,Sarkar-Tyson, Mitali,Marshall, Laura E.,Schweimer, Kristian,Bruhn, Heike,R?sch, Paul,Harmer, Nicholas J.,Sotriffer, Christoph A.,Holzgrabe, Ulrike
, p. 5134 - 5147 (2016/10/24)
The bacteria Burkholderia pseudomallei and Legionella pneumophila cause severe diseases like melioidosis and Legionnaire's disease with high mortality rates despite antibiotic treatment. Due to increasing antibiotic resistances against these and other Gram-negative bacteria, alternative therapeutical strategies are in urgent demand. As a virulence factor, the macrophage infectivity potentiator (Mip) protein constitutes an attractive target. The Mip proteins of B. pseudomallei and L. pneumophila exhibit peptidyl-prolyl cis/trans isomerase (PPIase) activity and belong to the PPIase superfamily. In previous studies, the pipecolic acid moiety proved to be a valuable scaffold for inhibiting this PPIase activity. Thus, a library of pipecolic acid derivatives was established guided by structural information and computational analyses of the binding site and possible binding modes. Stability and toxicity considerations were taken into account in iterative extensions of the library. Synthesis and evaluation of the compounds in PPIase assays resulted in highly active inhibitors. The activities can be interpreted in terms of a common binding mode obtained by docking calculations.
A new and convenient synthesis of 1-benzyl-1-azaspiro [5.5] undecan-7-one: A formal synthesis of (±)-perhydrohistrio-nicotoxin
Compain,Gore,Vatele
, p. 3075 - 3080 (2007/10/03)
A rapid, three-step synthesis of the title compound 3 in 40% overall yield from (±)-pipecolinic acid, is described.