180081-16-7

Basic information

• Product Name: Carbamic acid, [2-(4-aminophenyl)-1,1-dimethylethyl]-, 1,1-dimethylethyl ester
• CAS NO: 180081-16-7
• Molecular Formula: C15H24N2O2
• Molecular Weight: 264.368
• Mol File: 180081-16-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-(4-aminophenyl)-1,1-dimethylethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-(4-aminophenyl)-1,1-dimethylethyl]-, 1,1-dimethylethyl ester(180081-16-7)
• EPA Substance Registry System: Carbamic acid, [2-(4-aminophenyl)-1,1-dimethylethyl]-, 1,1-dimethylethyl ester(180081-16-7)

Safety Data

• Hazardous Substances Data: 180081-16-7(Hazardous Substances Data)

Upstream product

• 34405-42-0 α-(1-amino-1-methylethyl)benzenemethanol 
• 33687-74-0 1-phenyl-2-methyl-2-nitropropanol 
• 122-09-8 Phentermin 
• 82408-64-8 N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine 
• 541-16-2 t-butyl malonate 
• 51131-55-6 4-(β-amino-isobutyl)-aniline 
• 180081-15-6 tert-butyl N-[2-methyl-1-(4-nitrophenyl)-2-propyl]carbamate 

Downstream Products

• 1198312-16-1 C₂₁H₂₇N₃O₆S 
• 1355183-44-6 C₂₇H₃₄N₂O₄ 
• 1355183-58-2 C₂₃H₃₂N₂O₃ 
• 1198312-18-3 C₂₁H₂₉N₃O₄S 

Relevant articles and documents

Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof

Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.

Synthesis and evaluation of novel phenylethanolamine derivatives containing acetanilides as potent and selective b 3-adrenergic receptor agonists

In the search for potent and selective human β3-adrenergic receptor (AR) agonists as potential pharmacotherapies for the treatment of obesity and non-insulin dependent (type II) diabetes, we prepared a novel series of phenylethanolamine derivatives containing acetanilides and evaluated their biological activities at the human β3-, β2-, and β1-ARs. Among these compounds, the 6-amino-2-pyridylacetanilide (36b), 2-amino-5- methylthiazol- 4-ylacetanilide (36g), and 5-amino-1,2,4-thiadiazol-3- ylacetanilide (36h) derivatives showed potent agonistic activity at the β3-AR with functional selectivity over the β1- and β2-ARs. In addition, these compounds exhibited significant hypoglycemic activity in a rodent diabetic model.

Aniline derivatives possessing an inhibitory effect of nitric oxide synthase

Compounds represented by the general formula (1): ? (where R1is SR6or NR7R8, where R6is typically an alkyl group having 1-6 carbon atoms, R7is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a nitro group, and R8is a hydrogen atom or an alkyl group having 1-6 carbon atoms; R2and R3are each typically a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4is a hydrogen atom, an alkyl group having 1-6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5is a hydrogen atom or an alkyl group having 1-6 carbon atoms; Y1, Y2, Y3and Y4which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1-6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof. The compounds possess a potent nitric oxide synthase inhibiting activity and are useful as therapeutics of cerebrovascular diseases.